Studying The Role Of Cartilago Oligomer Matrix Protein (Comp) In Joint Structure Changes In Osteoarthritis
DOI:
https://doi.org/10.62480/tjms.2024.vol39.pp71-77Keywords:
osteoarthritis, cartilage oligomeric matrix protein, radiographic changesAbstract
To study the role of cartilage oligomeric matrix protein in structural changes in joints in patients with osteoarthritis (OA). Material and methods: We observed 50 patients diagnosed with osteoarthritis aged 54.5±4.4 years, of whom 43.8% had radiographic stage 0, 40% had stage I, and 16.2% had stage II. Patients in the main group received treatment aimed at reducing the amount of cartilage oligomeric matrix protein, while patients in the control group received traditional treatment. Results: In addition to clinical improvement and a decrease in the intensity of pain in the knee joint, patients in the main group also had lower levels of SOMP, CRP, and ESR in the blood serum compared to patients in the control group. Conclusions: The treatment method aimed at the dynamics of COMP differs from the traditional one in that it is aimed at suppressing the reactions of cartilage destruction in OA
References
Akhmedov Kh.S., Buranova S.N., Razakova F.S. The Importance of Treatment Aimed at the
Dynamics of Cartilage Oligomer Matrix Protein (COMP) in Patients with the Knee Joint Osteoarthritis //
Amer. J. Med. Med. Sci. – 2021. – – Vol. 11, №2. – P.148-153.
Altobelli E. et al. Synovial fluid and serum concentrations of inflammatory markers in rheumatoid
arthritis, psoriatic arthritis and osteoarthitis: a systematic review // Curr. Rheumatol. Rev. – 2017. – Vol. 13,
№3. – P. 170-179.
Bruyère O. et al. A consensus statement on the European Society for Clinical and Economic Aspects
of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis – from
evidence-based medicine to the real-life setting // Sem. Arthritis Rheum. – 2016. – Vol. 45, №4. – P. 3-11.
Dell`Isola A. Classification of patients with knee osteoarthritis in clinical phenotypes: data from the
osteoarthritis initiative // PLoS One. – 2018. – 13, №1.
Dragos D. et al. Phytomedicine in joint disorders // Nutrients. – 2017. – Vol. 9, №1. – P. 70.
Felson D.T., Niu J., Guermazi A. Defining radiographic incidence and progression of knee
osteoarthritis: suggested modifications of the Kellgren and Lawrence scale // Ann. Rheum. Dis. – 2011. –
Vol. 70, №11. – Р. 1884-1886.
Fernandes F.A., Pucinelli M.L., Silva N.P., Feldman D. Serum cartilage oligomeric matrix protein
(COMP) levels in knee osteoarthritis in a Brazilian population: Clinical and radiological correlation //
Scand. J. Rheumatol. – 2017. – Vol. 36. – Р. 211-215.
Hoch J.M. Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee
osteoarthritis: a systematic review and meta-analysis // Osteoarthritis Cartilage. – 2011. – Vol. 19, №12. –P.
-1404.
Hochberg M.C. et al. American College of Rheumatology 2012 recommendations for the use of
nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee // Arthritis Сare
Res. – 2012. – Vol. 64, №4. – P. 465-474.
Lotz M. et al. Republished: Value of biomarkers in osteoarthritis: current status and perspectives //
Postgrad. Med. J – 2014. – Vol. 90 №1061. – P. 171-178.
Luyten F.P., Denti M., Filardo G., Kon E., Engebretsen L. Definition and classification of early
osteoarthritis of the knee // Knee Surg., Sports Traumatol. Arthrosc. – 2012. – Vol. 20, №3. – P. 401-406.
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