Clinical Pharmacology Of Metabolism-Activating And Correcting Drugs

Authors

  • Urinboev L.X. Assistant of the Department of pharmacology, clinical pharmacology and medical biotechnology ASMI

DOI:

https://doi.org/10.62480/tjms.2025.vol42.pp48-50

Keywords:

therapeutic action, biotransformation of substances

Abstract

The article covers the issues of drug metabolism in patients with various liver diseases, presents pathophysiological mechanisms of impaired biotransformation of substances depending on the severity of hepatocyte damage, names the causes of drug interactions of pharmacological agents, leading to an undesirable increase in the concentration of the drug in the blood, strengthening and prolongation of the therapeutic effect with an increased risk of side effects

References

Diseases of the liver and biliary tract. A manual for physicians. Ed. by V. T. Ivashkin. Moscow: MVesti Publishing House, 2012: 10–247.

Ilchenko L. Yu., Vinnitskaya E. V., Vasnev O. S., Petrakov A. V., Shlyakhovsky I. A. The problem

of diagnostics and treatment of the main liver complications. Pharmateka. 2017; 2: 71–78.

Karkishchenko N. N., Khoronko V. V., Sergeeva S. A., Karkishchenko V. N. Pharmacokinetics.

Rostov-on-Don: Phoenix, 2011: 384 p.

Komissarenko I. A., Lazebnik L. B., Mikheeva O. M. Features of metabolism of antihypertensive

drugs in patients with pathology of the digestive organs. Cardiovascular therapy and prevention.

Supplement 1. 2019;8(6):239.

Kukes V.G., Starodubtsev A.K. Clinical pharmacology and pharmacotherapy. Moscow: GEOTARMed, 2013:227 p.

Lazebnik L.B., Komissarenko I.A., Mikheeva O.M. Treatment of arterial hypertension in patients

with liver pathology. Pharmateka. 2014;1:16–9.

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Published

2025-03-12

Issue

Vol. 42 (2025): TJMS

Section

Articles

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How to Cite

Clinical Pharmacology Of Metabolism-Activating And Correcting Drugs. (2025). Texas Journal of Medical Science, 42, 48-50. https://doi.org/10.62480/tjms.2025.vol42.pp48-50